Benefits on Usage of Mucolytics
Type of Drug:
Respiratory inhalant, drug that thins mucus.
How the Drug Works:
Acetylcysteine decreases the thickness and stickiness of mucus secretions of the lung, making them easier to cough up, and therefore promoting removal (expectoration) of this fluid.
Dornase alfa decreases the thickness and stickiness of mucus secretions of cystic fibrosis patients.
Acetylcysteine: To treat abnormally thick mucus secretions in chronic emphysema, emphysema with bronchitis, chronic asthmatic bronchitis, tuberculosis, bronchiectasis (chronic dilation of the airways), pneumonia, bronchitis, tacheobronchitis, cystic fibrosis, and other conditions involving excess mucus accumulation in the lung that is significant enough to affect breathing.
To reduce abnormally thick mucus secretion during tracheostomy care and diagnostic bronchial tests (eg, bronchograms, bronchospirometry, bronchial wedge catheterization).
To reduce abnormally thick mucus secretions during anesthesia in or after surgery or chest injuries.
As an emergency oral antidote drug to decrease liver damage after acetaminophen (eg, Tylenol) poisoning.
Dornase alfa: To reduce frequency of respiratory infections requiring parenteral (injectable) antibiotics and to improve pulmonary function in conjunction with standard therapies for patients with cystic fibrosis.
Unlabeled Uses: Occasionally, doctors may prescribe acetylcysteine as an eye solution to treat severe dry eyes or as an enema to treat bowel obstruction.
Do not use in the following situations: Allergy to acetylcysteine, dornase alfa, Chinese hamster ovary cell products (dornase alfa only), or any other ingredients within the drug.
Prolonged use: Safety and effectiveness of daily administration of dornase alfa for longer than 12 months have not been established.
Pregnancy: There are no adequate or well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits to the mother outweigh the possible hazards to the fetus.
Breastfeeding: It is not known if acetylcysteine or dornase alfa appear in breast milk. Consult your doctor before you begin breastfeeding.
Children: Safety and effectiveness of dornase alfa in children younger than 5 years of age have not been established.
Every drug is capable of producing side effects. Many mucolytic users experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:
Respiratory System: Increased mucus; runny nose; sore throat; voice changes; voice loss; cough; difficulty breathing; bronchitis; bronchspasm (spasm of the air tubes); chest tightness.
Digestive Tract: Nausea; vomiting; stomach pain; mouth inflammation.
Other: Fever; rash; drowsiness; eye inflammation; clamminess.
Guidelines for Use:
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